- Thursday, December 8th 2016 at 15:00 - 16:00 UK (Other timezones)
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Anxiety entails a variety of adaptive behaviours, physiological responses, and feelings that need to be optimized and coordinated in a given situation. In this presentation, I will recast anxiety as a decision problem and ask, what are algorithms and neural controllers that govern action selection under threat. Non-human animal data tentatively suggest an architecture that relies on tailored algorithms for specific threat scenarios. Virtual reality computer games provide an opportunity to test such a model in humans. I will present the translation of rodent anxiety paradigms to humans, together with pharmacological and fMRI data to support the cross-species validity of this translation. I will then focus on behavioural inhibition (BI), a specific behaviour under AAC and analyse the normativity, algorithmic implementation, and neural control of this behaviour. This framework provides a means to understand symptom generation in anxiety disorders.
Division of Clinical Psychiatry Research, University of Zurich, Switzerland
Wellcome Trust Centre for Neuroimaging, University College London, UK