The basal ganglia are a group of interconnected subcortical nuclei that plays a key role in multiple motor and cognitive processes, in a close interplay with several cortical regions. Two conflicting theories postulate that the basal ganglia pathways can either foster or suppress the cortico-striatal output or, alternatively, they can stabilize or destabilize the cortico-striatal circuit dynamics. These different approaches significantly impact the understanding of observable behaviours and cognitive processes in healthy, as well as clinical populations. In this talk I will present a case in support of the second model of basal ganglia dynamics, based on simulated neural network dynamics, as well as behavioural and MRI data.






Vincenzo G Fiore
Assistant Professor
Center for Computational Psychiatry
Department of Psychiatry, Icahn School
of Medicine at Mount Sinai, New York, NY, USA.



Vincenzo Fiore – Cortico-striatal dynamics: a slow changeover