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Group-level differences disguise a large biological heterogeneity and extreme inter-individual differences between patients with the same mental disorder. This strongly suggests that the ‘average patient’ is a non-informative construct in psychiatry, that falls apart when mapping abnormalities at the level of the individual patient. Here, we present a workable route towards precision medicine in psychiatry after a general introduction to pattern recognition methodology in the context of mental disorders. Further, we address the main challenges the field confronted in the last twenty years and present an outlook on the future by introducing two principles a refinement by integration and heterogeneity mapping through normative models.
Thomas Wolfers, MSc
Donders Centre for Cognitive Neuroimagin
Donders Institute for Brain, Cognition and Behaviour
Radboud University