- Wednesday, February 14th 2024 at 16:00 - 17:00 UK (Other timezones)
- General participation info | Participate online | + Phone in Meeting ID: 972 4297 4350 Passcode: 205293 Find your local number: https://ucl.zoom.us/u/aedyEiW1A6
Response inhibition, the ability to stop prepotent responses or inappropriate actions is an important cognitive function, central to understanding substance use and conditions such as Attention-Deficit/Hyperactivity Disorder (ADHD). However, ‘response inhibition’, is not a unitary construct, and behavioral measures often correlate poorly with neuroimaging data. A fuller appreciation of the mechanistic processes underlying response inhibition, including processes that were unmodelled previously, should lead to improved associations with neuroimaging data and to better correlations with real-world outcomes. Here, a Racing Diffusion Ex-Gaussian (RDEX) model was applied to a large sample (n>1,000) at two time points (at ages 19 and 23 years-old). Parameters from the RDEX model resulted in improved predictions of stop-signal reaction time using brain connectomic data, relative to a non-parametric model. Brain networks associated with RDEX parameters were also better predictors of cigarette and cannabis use.
Prof. Robert Whelan,
Professor in Psychology at Trinity College Dublin
Robert Whelan is a Professor in Psychology in the Global Brain Health Institute and the School of Psychology, Trinity College Dublin and is a principal investigator in the Trinity College Institute of Neuroscience. His research is directed at clinically relevant questions, using both structural and functional magnetic resonance imaging, high-density electroencephalography and behavioural assays. Many of his projects can be placed under the rubric of ‘Big Data’.